21cmDeepLearning extracts the underlying matter density map from a 21 cm intensity field by making use of a convolutional neural network (CNN) with the U-Net architecture; the software is implemented in Pytorch. The astrophysical parameters of the simulations can be predicted with a secondary CNN. The simulations of matter density and 21 cm maps are performed with the code 21cmFAST (ascl:1102.023).