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Astropy provides a common framework, core package of code, and affiliated packages for astronomy in Python. Development is actively ongoing, with major packages such as PyFITS, PyWCS, vo, and asciitable already merged in. Astropy is intended to contain much of the core functionality and some common tools needed for performing astronomy and astrophysics with Python.
Halotools builds and tests models of the galaxy-halo connection and analyzes catalogs of dark matter halos. The core functions of the package include fast generation of synthetic galaxy populations using HODs, abundance matching, and related methods; efficient algorithms for calculating galaxy clustering, lensing, z-space distortions, and other astronomical statistics; a modular, object-oriented framework for designing galaxy evolution models; and end-to-end support for reducing halo catalogs and caching them as hdf5 files.
Photutils provides tools for detecting and performing photometry of astronomical sources. It can estimate the background and background rms in astronomical images, detect sources in astronomical images, estimate morphological parameters of those sources (e.g., centroid and shape parameters), and perform aperture and PSF photometry. Written in Python, it is an affiliated package of Astropy (ascl:1304.002).
SNCosmo synthesizes supernova spectra and photometry from SN models, and has functions for fitting and sampling SN model parameters given photometric light curve data. It offers fast implementations of several commonly used extinction laws and can be used to construct SN models that include dust. The SNCosmo library includes supernova models such as SALT2, MLCS2k2, Hsiao, Nugent, PSNID, SNANA and Whalen models, as well as a variety of built-in bandpasses and magnitude systems, and provides convenience functions for reading and writing peculiar data formats used in other packages. The library is extensible, allowing new models, bandpasses, and magnitude systems to be defined using an object-oriented interface.
Astroquery allows users to access online astronomical data from a wide range of sources; it is an Astropy-affiliated package. Each web service has its own sub-package for interfacing with a particular data source.