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pyilc implements the needlet internal linear combination (NILC) algorithm for CMB component separation in pure Python; it also implements harmonic-space ILC. The code can also perform Cross-ILC, where the covariance matrices are computed only from independent splits of the maps. In addition, pyilc includes an inpainting code, diffusive_inpaint, that diffusively inpaints a masked region with the mean of the unmasked neighboring pixels.